At its most fundamental level, quantum science has raised some serious questions about the nature of reality. Such phenomenon as entanglement, quantum indeterminacy, and the observer effect point to the need for a deeper look at the behavior of matter and energy on the atomic and subatomic level. One path of study postulates the idea that we are living in a simulated universe. There are many researchers and scientists who say we are likely living in an extremely powerful computer program (think The Matrix). If it is true that we are living in a video game, the likelihood is that it is a massive, multiplayer, online, role-playing game. In this fascinating dialogue we cover such topics as: Is there such a thing as physical reality or are we living in a great simulation of information and computation? Is this a material universe or a simulated one? Are all our deeds and quests being kept track of in the “cloud” like an angel recording our lives? Who is running the game? Why, if it is a video game, why don’t we choose bliss? What is the connection between computer science, video game physics and the great spiritual traditions such as Hinduism, Christianity, Islam, Judaism, and others?